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Create New Ways to Prevent or Cure HIV Infection (Round 2)

Roadblock:

The HIV epidemic is taking an enormous toll in the lives of millions of people, particularly in the developing world. Efficient methods of preventing transmission, infection, and the effects of the virus have remained elusive. Cellular or antibody-based approaches for traditional HIV vaccines have not yet yielded measures of efficacy for either prevention or therapy.

Create New Ways of Protecting Against Infectious Diseases (Round 2)

Roadblock:

Vaccines have been a cornerstone of global health campaigns to provide protection against infectious diseases. However, discovery of new vaccines currently relies on a long and costly process of trial and error, and this approach has an uneven record of success. The proliferation of novel antigens, adjuvants, and formulations require new methods to more reliably select those entities that will elicit protective immune responses in humans.

Create New Tools to Accelerate the Eradication of Malaria (Round 2)

Roadblock:

Thanks to recent progress against malaria, the global eradication of the disease has emerged as a feasible long-term goal. However, eradicating malaria will require innovative new tools and approaches to stop transmission of malaria from human and mosquito reservoirs.

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