The Antifungal Therapeutic Effects of Sertraline in HIV-Infected Adults with Cryptococcal Meningitis

Cryptococcal meningitis has emerged as a frequent and deadly infection in AIDS patients. High mortality is compounded by the high cost, toxicity, and limited repertoire of available antifungals. Researchers at the Infectious Diseases Institute in Kampala, Uganda, will determine if adding the antidepressant sertraline to standard therapy will result in better treatment of cryptococcal meningitis.