Trojan Horse Vaccines for HIV Based on Lentiviral Vectors Expressing Suicide Envelopes

To provoke an effective immune response against HIV, George Dickson of Royal Holloway -University of London will utilize HIV-based lentivectors encoded with a strong neutralizing epitope derived from tetanus toxin or influenza on its surface. By forcing production of such highly immunogenic and stable antigens, the immune system will respond with corresponding antibodies and control virus replication.