Development of Toxoplasma Multi-Protein Sub-Unit Vaccine and Their Experiment Trials in Mouse Model Administered Intranasally with Triad of Antigens Formulated in Nanoparticles

Problem: Toxoplasma gondii is the cause of toxoplasmosis in man and animals. To date, no vaccine is available in human to control the disease. In this project, a multiprotein vaccine will be developed using ROP18, SAG1 and AMA1. The recombinant proteins will be encapsulated in nanoparticles and administrated intranasally in mice. Future Perspectives: To develop vaccine strategy in sheep and humans because one third of our earth's population is infected with toxoplasmosis, and it causes abortions in sheep.