A Protein-Based Method To Distinguish Seroprevalence In Humans For Multiple Mosquito-Borne Flaviviruses

Design a high-throughput peptide array technology to identify immunodominant peptides capable of distinguishing 10 Flavivirus taxa. Using the identified immunodominant peptides, the team will generate an indirect ELISA protocol that can be used in developing countries to accurately measure the seroprevalence of multiple Flavivirus species simultaneously, including ZIKV and be developed further into a point-of-care diagnostic.