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Forty-three researchers from 12 countries were awarded initial grants under Grand Challenges Explorations. Read summaries of these grants awarded for the Round 16 challenges: Explore New Solutions in Global Health Priority Areas; Novel Approaches to Characterizing and Tracking the Global Burden of Antimicrobial Resistance; Addressing Newborn and Infant Gut Health Through Bacteriophage-Mediated Microbiome Engineering; Explore New Ways to Measure Delivery and Use of Digital Financial Services Data