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This new Grand Challenges program focuses on innovative concepts for vaccines, therapeutics, and diagnostics with the potential to be translated into safe, effective, affordable, and widely utilized interventions to protect against the acquisition, progression, or transmission of infectious diseases, or to provide a cure for infectious diseases, in resource‐limited settings. The program will fund full awards and pilot awards – full awards must include an industry, biotech, or other translational partner, either leading or participating in the project.