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Improving Influenza and Typhoid Vaccine Efficacy with Fortification Iron in Iron-Deficient Thai Women

Nicole Stoffel of the University of Oxford in the United Kingdom together with Pattanee Winichagoon of Mahidol University in Thailand will perform a double-blind randomized controlled trial to test whether providing iron-fortified food to iron-deficient women in Thailand improves their immune response to vaccination. Vaccines underperform in low- and middle-income countries, which may be caused by poor nutrition. Iron deficiency is common, and iron may play a key role in adaptive immunity and vaccine response. Preliminary data from their earlier study in Kenya showed that women given intravenous iron one week before a vaccine produced significantly more antibodies. To translate this to low-resource settings, they will perform a trial of 180 women in northeastern Thailand and provide half of them with a wheat-flour-based baked snack fortified with iron for forty days and test its effect on their immune response to two vaccine types: an intramuscular influenza vaccine and an oral typhoid vaccine.

Grant ID
INV-046327
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Follow-on Funding
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Lead Funding Organization
Initiatives
Principal Investigator
Individual Funder Information
Funding Amount (in original currency)
219933.00
Funding Currency
USD
Funding Amount (in USD)
219933.00
Project Type
Project Primary Sector
Funding Date Range
-
Funding Total (In US dollars)
219933.00
Co-Funded
False