Interruption of Latency and In Vivo Adenovirus-Mediated Elimination of Macrophages Infected with M. Tuberculosis

Pulmonary macrophages are the principal host of tuberculosis, where it can remain latent and inaccessible to current TB drug therapies. Dmitry Shayakhmetov of the University of Washington will study whether infecting these host cells with adenovirus will induce rapid cell death, reducing TB load and blocking the re-infection cycle.