Molecular Analysis and Modeling of HIV-1 Transmission, Containment and Escape

Dr. Shaw is leading a consortium of investigators from clinical and laboratory research sites in Africa, the Caribbean, and the United States. They are conducting a comprehensive, integrated analysis of humoral and cellular responses to HIV-1 in people in early and acute stages of infection. Investigators are basing their work on the hypothesis that HIV-1 leads to chronic, persistent infection rather than a rapidly lethal disease because elements of the human immune system partially constrain viral replication over long periods. Ultimately, the project's goal is to contribute to the development of vaccines for HIV and AIDS through better understanding of natural immune response to the virus. Shaw (Grand Challenges in Global Health: 2005-2015 retrospective)